A Novel Mouse Model for the Hyper-IgM Syndrome: A Spontaneous Activation-Induced Cytidine Deaminase Mutation Leading to Complete Loss of Ig Class Switching and Reduced Somatic Hypermutation

We describe a spontaneously derived mouse line that completely failed to induce Ig class switching in vitro and in vivo. The mice inherited abolished IgG serum titers in a recessive manner caused by a spontaneous G→A transition mutation in codon 112 of the aicda gene, leading to an arginine to histi...

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Detalhes bibliográficos
Main Authors: Dahlberg, Carin I. M., He, Minghui, Visnes, Torkild, Torres, Magda Liz, Cortizas, Elena M., Verdun, Ramiro E., Westerberg, Lisa S., Severinson, Eva, Ström, Lena
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Novel Immunological Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201989/
https://ncbi.nlm.nih.gov/pubmed/25252954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401242
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