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mTORC1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function

The mammalian target of rapamcyin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in controlling immune responses. Emerging evidence suggests that these two functions of mTORC1 are integrally linked. However, little is known regarding mTORC1 function in co...

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Autors principals: Donnelly, Raymond P., Loftus, Róisín M., Keating, Sinéad E., Liou, Kevin T., Biron, Christine A., Gardiner, Clair M., Finlay, David K.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201970/
https://ncbi.nlm.nih.gov/pubmed/25261477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401558
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