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mTORC1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function

The mammalian target of rapamcyin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in controlling immune responses. Emerging evidence suggests that these two functions of mTORC1 are integrally linked. However, little is known regarding mTORC1 function in co...

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Detalhes bibliográficos
Main Authors: Donnelly, Raymond P., Loftus, Róisín M., Keating, Sinéad E., Liou, Kevin T., Biron, Christine A., Gardiner, Clair M., Finlay, David K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201970/
https://ncbi.nlm.nih.gov/pubmed/25261477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401558
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