Diminished Viral Control during SIV Infection is Associated with Aberrant PD-1(hi) CD4 T cell Enrichment in the Lymphoid Follicles of the Rectal Mucosa

The inhibitory receptor Programmed Death-1 (PD-1) has been shown to regulate CD8 T cell function during chronic SIV infection, however its role on CD4 T cells, specifically in the gut associated lymphoid tissue, is less well understood. Here, we show that a subset of CD4 T cells express high levels...

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Main Authors: Mylvaganam, Geetha H., Velu, Vijayakumar, Hong, Jung-Joo, Sadagopal, Shanmugalakshmi, Kwa, Suefen, Basu, Rahul, Lawson, Benton, Villinger, Francois, Amara, Rama Rao
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201952/
https://ncbi.nlm.nih.gov/pubmed/25246494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401222
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