ロード中...
Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
The tumor suppressor protein Par-4, which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds to vimentin, displaces...
保存先:
| 主要な著者: | , , , , , , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201913/ https://ncbi.nlm.nih.gov/pubmed/25218743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1631 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|