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Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
The tumor suppressor protein Par-4, which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds to vimentin, displaces...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201913/ https://ncbi.nlm.nih.gov/pubmed/25218743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1631 |
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