A Roadmap for Natural Product Discovery Based on Large-Scale Genomics and Metabolomics

Actinobacteria encode a wealth of natural product biosynthetic gene clusters (NPGCs), whose systematic study is complicated by numerous repetitive motifs. By combining several metrics we developed a method for global classification of these gene clusters into families (GCFs) and analyzed the biosynt...

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Bibliografiske detaljer
Main Authors: Doroghazi, James R., Albright, Jessica C., Goering, Anthony W., Ju, Kou-San, Haines, Robert R., Tchalukov, Konstantin A., Labeda, David P., Kelleher, Neil L., Metcalf, William W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201863/
https://ncbi.nlm.nih.gov/pubmed/25262415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1659
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