The Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB has a Structured N-terminus that Influences Potency

Among the μ-conotoxins that block vertebrate voltage-gated sodium channels (VGSCs), some have been shown to be potent analgesics following systemic administration in mice. We have determined the solution structure of a new representative of this family, μ-BuIIIB, and established its disulfide connec...

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Autores principales: Kuang, Zhihe, Zhang, Min-Min, Gupta, Kallol, Gajewiak, Joanna, Gulyas, Jozsef, Balaram, Padmanabhan, Rivier, Jean E., Olivera, Baldomero M., Yoshikami, Doju, Bulaj, Grzegorz, Norton, Raymond S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201638/
https://ncbi.nlm.nih.gov/pubmed/23557677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300674x
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