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Asymmetric Synthesis of a CBI-Based Cyclic N-Acyl O-Amino Phenol Duocarmycin Prodrug

[Image: see text] A short, asymmetric synthesis of a cyclic N-acyl O-amino phenol duocarmycin prodrug subject to reductive activation based on the simplified 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) DNA alkylation subunit is described. A key element of the approach entailed treatment...

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Main Authors: Uematsu, Mika, Boger, Dale L.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201355/
https://ncbi.nlm.nih.gov/pubmed/25247380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo501839x
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