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Efficacious Cyclic N-Acyl O-Amino Phenol Duocarmycin Prodrugs
Two novel cyclic N-acyl O-amino phenol prodrugs are reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family of natural products. These prodrugs were explored with the expectation that they may be cleaved selectively within hypoxic tumor environments that h...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687800/ https://ncbi.nlm.nih.gov/pubmed/23627265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400413r |
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