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A Novel, Unusually Efficacious Duocarmycin Carbamate Prodrug That Releases No Residual Byproduct
A unique heterocyclic carbamate prodrug of seco-CBI-indole(2) that releases no residual byproduct is reported as a new member of a class of hydrolyzable prodrugs of the duocarmycin and CC-1065 family of natural products. The prodrug was designed to be activated by hydrolysis of a carbamate releasing...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386426/ https://ncbi.nlm.nih.gov/pubmed/22650244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300330b |
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