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A Novel, Unusually Efficacious Duocarmycin Carbamate Prodrug That Releases No Residual Byproduct

A unique heterocyclic carbamate prodrug of seco-CBI-indole(2) that releases no residual byproduct is reported as a new member of a class of hydrolyzable prodrugs of the duocarmycin and CC-1065 family of natural products. The prodrug was designed to be activated by hydrolysis of a carbamate releasing...

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Main Authors: Wolfe, Amanda L., Duncan, Katharine K., Parelkar, Nikhil K., Weir, Scott J., Vielhauer, George A., Boger, Dale L.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386426/
https://ncbi.nlm.nih.gov/pubmed/22650244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300330b
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