γCaMKII shuttles Ca(2+)/CaM to the nucleus to trigger CREB phosphorylation and gene expression

Activity-dependent CREB phosphorylation and gene expression are critical for long-term neuronal plasticity. Local signaling at Ca(V)1 channels triggers these events but how information is relayed onward to the nucleus remains unclear. Here we report a novel mechanism that mediates long-distance comm...

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Bibliographic Details
Main Authors: Ma, Huan, Groth, Rachel D., Cohen, Samuel M., Emery, John F., Li, Bo-Xing, Hoedt, Esthelle, Zhang, Guo-An, Neubert, Thomas A., Tsien, Richard W.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201038/
https://ncbi.nlm.nih.gov/pubmed/25303525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.019
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