γCaMKII shuttles Ca(2+)/CaM to the nucleus to trigger CREB phosphorylation and gene expression

Activity-dependent CREB phosphorylation and gene expression are critical for long-term neuronal plasticity. Local signaling at Ca(V)1 channels triggers these events but how information is relayed onward to the nucleus remains unclear. Here we report a novel mechanism that mediates long-distance comm...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ma, Huan, Groth, Rachel D., Cohen, Samuel M., Emery, John F., Li, Bo-Xing, Hoedt, Esthelle, Zhang, Guo-An, Neubert, Thomas A., Tsien, Richard W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201038/
https://ncbi.nlm.nih.gov/pubmed/25303525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.019
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky