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MicroRNA-96 inhibits FoxO3a function in IPF fibroblasts on type I collagen matrix

Idiopathic pulmonary fibrosis (IPF) is a lethal and progressive lung disease characterized by persistent (myo)fibroblasts and the relentless accumulation of collagen matrix. Unlike normal lung fibroblasts, IPF lung fibroblasts have suppressed forkhead box O3a (FoxO3a) activity, which allows them to...

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Detalhes bibliográficos
Main Authors: Nho, Richard Seonghun, Im, Jintaek, Ho, Yen-Yi, Hergert, Polla
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200385/
https://ncbi.nlm.nih.gov/pubmed/25172912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00127.2014
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