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Reduced FoxO3a expression causes low autophagy in idiopathic pulmonary fibrosis fibroblasts on collagen matrices

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease, and fibroblasts derived from patients with IPF are resistant to type I collagen matrix-induced cell death. The alteration of the PTEN-Akt axis permits IPF fibroblasts to maintain a pathological phenotype on collagen by suppress...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Lung Cell Mol Physiol
Hoofdauteurs: Im, Jintaek, Hergert, Polla, Nho, Richard Seonghun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572418/
https://ncbi.nlm.nih.gov/pubmed/26186945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00079.2015
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