LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis

AIMS: Lectin-like ox-LDL scavenger receptor-1 (LOX-1) and mitochondrial DNA (mtDNA) damage play a key role in a variety of cardiovascular diseases, including atherosclerosis, hypertension, and inflammation. We posited that damaged mtDNA could trigger autophagy and NLRP3 inflammasome activation, and...

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Bibliographic Details
Main Authors: Ding, Zufeng, Liu, Shijie, Wang, Xianwei, Dai, Yao, Khaidakov, Magomed, Deng, Xiaoyan, Fan, Yubo, Xiang, David, Mehta, Jawahar L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200051/
https://ncbi.nlm.nih.gov/pubmed/24776598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu114
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