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Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis
Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena. Experiments...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3546319/ https://ncbi.nlm.nih.gov/pubmed/23326634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01077 |
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