CRISPR-mediated direct mutation of cancer genes in the mouse liver

The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem (ES) cells(1). Here we describe a new method of cancer model generation using the CRISPR/Cas system in vivo in wild-type mice. We have used h...

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Bibliographische Detailangaben
Hauptverfasser: Xue, Wen, Chen, Sidi, Yin, Hao, Tammela, Tuomas, Papagiannakopoulos, Thales, Joshi, Nikhil S., Cai, Wenxin, Yang, Gillian, Bronson, Roderick, Crowley, Denise G., Zhang, Feng, Anderson, Daniel G., Sharp, Phillip A., Jacks, Tyler
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199937/
https://ncbi.nlm.nih.gov/pubmed/25119044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13589
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