Small RNA combination therapy for lung cancer

MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering miRNA mimics and siRNAs to lung adenocarcinoma cells in vitro and to tumor...

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Detalhes bibliográficos
Main Authors: Xue, Wen, Dahlman, James E., Tammela, Tuomas, Khan, Omar F., Sood, Sabina, Dave, Apeksha, Cai, Wenxin, Chirino, Leilani M., Yang, Gillian R., Bronson, Roderick, Crowley, Denise G., Sahay, Gaurav, Schroeder, Avi, Langer, Robert, Anderson, Daniel G., Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151750/
https://ncbi.nlm.nih.gov/pubmed/25114235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412686111
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