Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses

Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically-engineered mouse lung adenocarcinoma model and found Treg cells...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Joshi, Nikhil S., Akama-Garren, Elliot H., Lu, Yisi, Lee, Da-Yae, Chang, Gregory P., Li, Amy, DuPage, Michel, Tammela, Tuomas, Kerper, Natanya R., Farago, Anna F., Robbins, Rebecca, Crowley, Denise M., Bronson, Roderick T., Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826619/
https://ncbi.nlm.nih.gov/pubmed/26341400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.08.006
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