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Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression
Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respond...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069809/ https://ncbi.nlm.nih.gov/pubmed/21251614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.11.011 |
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