Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression

Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respond...

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Bibliografiset tiedot
Päätekijät: DuPage, Michel, Cheung, Ann, Mazumdar, Claire, Winslow, Monte M., Bronson, Roderick, Schmidt, Leah M., Crowley, Denise, Chen, Jianzhu, Jacks, Tyler
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069809/
https://ncbi.nlm.nih.gov/pubmed/21251614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.11.011
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