T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity

The T-cell receptor (TCR) repertoire is formed by random recombinations of genomic precursor elements; the resulting combinatorial diversity renders unlikely extensive TCR sharing between individuals. Here, we studied CDR3β amino acid sequence sharing in a repertoire-wide manner, using high-throughp...

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Détails bibliographiques
Auteurs principaux: Madi, Asaf, Shifrut, Eric, Reich-Zeliger, Shlomit, Gal, Hilah, Best, Katharine, Ndifon, Wilfred, Chain, Benjamin, Cohen, Irun R., Friedman, Nir
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199372/
https://ncbi.nlm.nih.gov/pubmed/25024161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.170753.113
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