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T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity
The T-cell receptor (TCR) repertoire is formed by random recombinations of genomic precursor elements; the resulting combinatorial diversity renders unlikely extensive TCR sharing between individuals. Here, we studied CDR3β amino acid sequence sharing in a repertoire-wide manner, using high-throughp...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4199372/ https://ncbi.nlm.nih.gov/pubmed/25024161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.170753.113 |
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