SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

Manganese (Mn) is an essential metal, but elevated cellular levels are toxic and may lead to the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn-induced parkinsonism generally occurs as a result of exposure to elevated Mn levels in occupational or environmental se...

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Main Authors: Leyva-Illades, Dinorah, Chen, Pan, Zogzas, Charles E., Hutchens, Steven, Mercado, Jonathan M., Swaim, Caleb D., Morrisett, Richard A., Bowman, Aaron B., Aschner, Michael, Mukhopadhyay, Somshuvra
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2014
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198546/
https://ncbi.nlm.nih.gov/pubmed/25319704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2329-14.2014
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