SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

Manganese (Mn) is an essential metal, but elevated cellular levels are toxic and may lead to the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn-induced parkinsonism generally occurs as a result of exposure to elevated Mn levels in occupational or environmental se...

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Main Authors: Leyva-Illades, Dinorah, Chen, Pan, Zogzas, Charles E., Hutchens, Steven, Mercado, Jonathan M., Swaim, Caleb D., Morrisett, Richard A., Bowman, Aaron B., Aschner, Michael, Mukhopadhyay, Somshuvra
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198546/
https://ncbi.nlm.nih.gov/pubmed/25319704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2329-14.2014
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