Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production

SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary manganese toxicity. Patients have elevated manganese in the blood and brain and develop neurotoxicity. Liver manganese is increased in p...

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Vydáno v:J Biol Chem
Hlavní autoři: Liu, Chunyi, Hutchens, Steven, Jursa, Thomas, Shawlot, William, Polishchuk, Elena V., Polishchuk, Roman S., Dray, Beth K., Gore, Andrea C., Aschner, Michael, Smith, Donald R., Mukhopadhyay, Somshuvra
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633123/
https://ncbi.nlm.nih.gov/pubmed/28860195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.804989
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