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Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice

Apolipoprotein (apo) E4 is expressed in many types of brain cells, is associated with age-dependent decline of learning and memory in humans, and is the major genetic risk factor for AD. To determine whether the detrimental effects of apoE4 depend on its cellular sources, we generated human apoE kno...

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書誌詳細
主要な著者: Knoferle, Johanna, Yoon, Seo Yeon, Walker, David, Leung, Laura, Gillespie, Anna K., Tong, Leslie M., Bien-Ly, Nga, Huang, Yadong
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198545/
https://ncbi.nlm.nih.gov/pubmed/25319703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2281-14.2014
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