Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice

Apolipoprotein (apo) E4 is expressed in many types of brain cells, is associated with age-dependent decline of learning and memory in humans, and is the major genetic risk factor for AD. To determine whether the detrimental effects of apoE4 depend on its cellular sources, we generated human apoE kno...

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Hauptverfasser: Knoferle, Johanna, Yoon, Seo Yeon, Walker, David, Leung, Laura, Gillespie, Anna K., Tong, Leslie M., Bien-Ly, Nga, Huang, Yadong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198545/
https://ncbi.nlm.nih.gov/pubmed/25319703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2281-14.2014
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