Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD). However, the underlying mechanisms are still poorly understood. We previously reported that female apoE4 knock-in (KI) mice had an age-dependent decline in hilar GABAergic interneurons that correlated with...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tong, Leslie M., Yoon, Seo Yeon, Andrews-Zwilling, Yaisa, Yang, Alyssa, Lin, Victoria, Lei, Hanci, Huang, Yadong
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756160/
https://ncbi.nlm.nih.gov/pubmed/26888940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3815-15.2016
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