Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD). However, the underlying mechanisms are still poorly understood. We previously reported that female apoE4 knock-in (KI) mice had an age-dependent decline in hilar GABAergic interneurons that correlated with...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Tong, Leslie M., Yoon, Seo Yeon, Andrews-Zwilling, Yaisa, Yang, Alyssa, Lin, Victoria, Lei, Hanci, Huang, Yadong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2016
Schlagworte:
Brief Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756160/
https://ncbi.nlm.nih.gov/pubmed/26888940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3815-15.2016
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