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Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD). However, the underlying mechanisms are still poorly understood. We previously reported that female apoE4 knock-in (KI) mice had an age-dependent decline in hilar GABAergic interneurons that correlated with...

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書誌詳細
出版年:J Neurosci
主要な著者: Tong, Leslie M., Yoon, Seo Yeon, Andrews-Zwilling, Yaisa, Yang, Alyssa, Lin, Victoria, Lei, Hanci, Huang, Yadong
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756160/
https://ncbi.nlm.nih.gov/pubmed/26888940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3815-15.2016
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