GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice

Apolipoprotein (apo) E has important and diverse functions in neurobiology, and apoE4 is the major known genetic risk factor for Alzheimer’s disease. Here we report that adult neural stem/progenitor cells (NSCs) express apoE. In apoE knockout mice, neurogenesis in the hippocampus was ~60% lower than...

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Autori principali: Li, Gang, Bien-Ly, Nga, Andrews-Zwilling, Yaisa, Xu, Qin, Bernardo, Aubrey, Ring, Karen, Halabisky, Brian, Deng, Changhui, Mahley, Robert W., Huang, Yadong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992822/
https://ncbi.nlm.nih.gov/pubmed/19951691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.10.015
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