Llwytho...

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice

Apolipoprotein (apo) E4 is the major known genetic risk factor for Alzheimer's disease (AD). We have shown in vitro and in vivo that apoE4 preferentially undergoes aberrant cleavage in neurons, yielding neurotoxic C-terminal-truncated fragments. To study the effect of these fragments on amyloid...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bien-Ly, Nga, Andrews-Zwilling, Yaisa, Xu, Qin, Bernardo, Aubrey, Wang, Charles, Huang, Yadong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053957/
https://ncbi.nlm.nih.gov/pubmed/21368138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018381108
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!