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C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice

Apolipoprotein (apo) E4 is the major known genetic risk factor for Alzheimer's disease (AD). We have shown in vitro and in vivo that apoE4 preferentially undergoes aberrant cleavage in neurons, yielding neurotoxic C-terminal-truncated fragments. To study the effect of these fragments on amyloid...

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Bibliographische Detailangaben
Hauptverfasser: Bien-Ly, Nga, Andrews-Zwilling, Yaisa, Xu, Qin, Bernardo, Aubrey, Wang, Charles, Huang, Yadong
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053957/
https://ncbi.nlm.nih.gov/pubmed/21368138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018381108
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