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Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent Aβ Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

Apolipoprotein E4 (apoE4) plays a major role in the pathogenesis of Alzheimer's disease. Brain amyloid-β (Aβ) accumulation depends on age and apoE isoforms (apoE4 > apoE3) both in humans and in transgenic mouse models. Brain apoE levels are also isoform dependent, but in the opposite directi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bien-Ly, Nga, Gillespie, Anna K., Walker, David, Yoon, Seo Yeon, Huang, Yadong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433173/
https://ncbi.nlm.nih.gov/pubmed/22492035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0033-12.2012
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