Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice

Apolipoprotein (apo) E4 is expressed in many types of brain cells, is associated with age-dependent decline of learning and memory in humans, and is the major genetic risk factor for AD. To determine whether the detrimental effects of apoE4 depend on its cellular sources, we generated human apoE kno...

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Hlavní autoři: Knoferle, Johanna, Yoon, Seo Yeon, Walker, David, Leung, Laura, Gillespie, Anna K., Tong, Leslie M., Bien-Ly, Nga, Huang, Yadong
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198545/
https://ncbi.nlm.nih.gov/pubmed/25319703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2281-14.2014
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