Catalytic Immunoglobulin Gene Delivery in a Mouse Model of Alzheimer's Disease: Prophylactic and Therapeutic Applications

Accumulation of amyloid beta-peptide (Aβ) in the brain is hypothesized to be a causal event leading to dementia in Alzheimer's disease (AD). Aβ vaccination removes Aβ deposits from the brain. Aβ immunotherapy, however, may cause T cell- and/or Fc-receptor-mediated brain inflammation and relocat...

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Hlavní autoři: Kou, Jinghong, Yang, Junling, Lim, Jeong-Eun, Pattanayak, Abhinandan, Song, Min, Planque, Stephanie, Paul, Sudhir, Fukuchi, Ken-ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198531/
https://ncbi.nlm.nih.gov/pubmed/24733587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8691-z
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