Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats. Knockdown and overexpression studies in human tumor cells showed that the shel...

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Bibliografski detalji
Glavni autori: Sexton, Alec N., Regalado, Samuel G., Lai, Christine S., Cost, Gregory J., O’Neil, Colleen M., Urnov, Fyodor D., Gregory, Philip D., Jaenisch, Rudolf, Collins, Kathleen, Hockemeyer, Dirk
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2014
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197946/
https://ncbi.nlm.nih.gov/pubmed/25128433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246819.114
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