Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats. Knockdown and overexpression studies in human tumor cells showed that the shel...

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Autores principales: Sexton, Alec N., Regalado, Samuel G., Lai, Christine S., Cost, Gregory J., O’Neil, Colleen M., Urnov, Fyodor D., Gregory, Philip D., Jaenisch, Rudolf, Collins, Kathleen, Hockemeyer, Dirk
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197946/
https://ncbi.nlm.nih.gov/pubmed/25128433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246819.114
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