Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats. Knockdown and overexpression studies in human tumor cells showed that the shel...

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Hlavní autoři: Sexton, Alec N., Regalado, Samuel G., Lai, Christine S., Cost, Gregory J., O’Neil, Colleen M., Urnov, Fyodor D., Gregory, Philip D., Jaenisch, Rudolf, Collins, Kathleen, Hockemeyer, Dirk
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197946/
https://ncbi.nlm.nih.gov/pubmed/25128433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246819.114
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