DNA Mapping Using Microfluidic Stretching and Single-Molecule Detection of Fluorescent Site-Specific Tags

We have developed a rapid molecular mapping technology—Direct Linear Analysis (DLA)—on the basis of the analysis of individual DNA molecules bound with sequence-specific fluorescent tags. The apparatus includes a microfluidic device for stretching DNA molecules in elongational flow that is coupled t...

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Hlavní autoři: Chan, Eugene Y., Goncalves, Nuno M., Haeusler, Rebecca A., Hatch, Amie J., Larson, Jonathan W., Maletta, Anthony M., Yantz, Gregory R., Carstea, Eugene D., Fuchs, Martin, Wong, Gordon G., Gullans, Steven R., Gilmanshin, Rudolf
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
Methods
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC419792/
https://ncbi.nlm.nih.gov/pubmed/15173119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1635204
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