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Application of single molecule technology to rapidly map long DNA and study the conformation of stretched DNA
Herein we describe the first application of direct linear analysis (DLA) to the mapping of a bacterial artificial chromosome (BAC), specifically the 185.1 kb-long BAC 12M9. DLA is a single molecule mapping technology, based on microfluidic elongation and interrogation of individual DNA molecules, se...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2005
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1266062/ https://ncbi.nlm.nih.gov/pubmed/16243782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki895 |
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