BIG3 inhibits insulin granule biogenesis and insulin secretion

While molecular regulation of insulin granule exocytosis is relatively well understood, insulin granule biogenesis and maturation and its influence on glucose homeostasis are relatively unclear. Here, we identify a novel protein highly expressed in insulin-secreting cells and name it BIG3 due to its...

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Bibliografiske detaljer
Main Authors: Li, Hongyu, Wei, Shunhui, Cheng, Kenneth, Gounko, Natalia V, Ericksen, Russell E, Xu, Aimin, Hong, Wanjin, Han, Weiping
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197882/
https://ncbi.nlm.nih.gov/pubmed/24711543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338181
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