Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells

Glucose stimulates insulin secretion from β-cells by increasing intracellular Ca(2+). Ca(2+) then binds to synaptotagmin-7 as a major Ca(2+) sensor for exocytosis, triggering secretory granule fusion and insulin secretion. In type-2 diabetes, insulin secretion is impaired; this impairment is amelior...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wu, Bingbing, Wei, Shunhui, Petersen, Natalia, Ali, Yusuf, Wang, Xiaorui, Bacaj, Taulant, Rorsman, Patrik, Hong, Wanjin, Südhof, Thomas C., Han, Weiping
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538675/
https://ncbi.nlm.nih.gov/pubmed/26216970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513004112
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