BIG3 inhibits insulin granule biogenesis and insulin secretion

While molecular regulation of insulin granule exocytosis is relatively well understood, insulin granule biogenesis and maturation and its influence on glucose homeostasis are relatively unclear. Here, we identify a novel protein highly expressed in insulin-secreting cells and name it BIG3 due to its...

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Autors principals: Li, Hongyu, Wei, Shunhui, Cheng, Kenneth, Gounko, Natalia V, Ericksen, Russell E, Xu, Aimin, Hong, Wanjin, Han, Weiping
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197882/
https://ncbi.nlm.nih.gov/pubmed/24711543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338181
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