Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression

BACKGROUND: Various kinase inhibitors are known to be ATP-binding cassette (ABC) transporter substrates and resistance acquisition to kinase inhibitors has been associated to increased ABC transporter expression. Here, we investigated the role of the ABC transporters ABCB1, ABCC1, and ABCG2 during m...

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Detalhes bibliográficos
Main Authors: Michaelis, Martin, Rothweiler, Florian, Nerreter, Thomas, van Rikxoort, Marijke, Zehner, Richard, Dirks, Wilhelm G, Wiese, Michael, Cinatl, Jindrich
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197243/
https://ncbi.nlm.nih.gov/pubmed/25300205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-710
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