Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

BACKGROUND: A molecular linkage between the MAPK and the LKB1-AMPK energy sensor pathways suggests that combined MAPK oncogene inhibition and metabolic modulation of AMPK would be more effective than either manipulation alone in melanoma cell lines. MATERIALS AND METHODS: The combination of the BRAF...

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Hauptverfasser: Niehr, Franziska, von Euw, Erika, Attar, Narsis, Guo, Deliang, Matsunaga, Doug, Sazegar, Hooman, Ng, Charles, Glaspy, John A, Recio, Juan A, Lo, Roger S, Mischel, Paul S, Comin-Anduix, Begonya, Ribas, Antoni
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152784/
https://ncbi.nlm.nih.gov/pubmed/21609436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-76
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