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Cytosolic DNA Sensing via the Stimulator of Interferon Genes (STING) Adaptor: The Yin and Yang of Immune Responses to DNA
DNA is immunogenic and many cells express cytosolic DNA sensors that activate the Stimulator of Interferon Genes (STING) adaptor to trigger interferon type I (IFN-β) release, a potent immune activator. DNA sensing to induce IFN-β triggers host immunity to pathogens but constitutive DNA sensing can i...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197080/ https://ncbi.nlm.nih.gov/pubmed/25143264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344407 |
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