Critical role of cytosolic DNA and its sensing adaptor STING in aortic degeneration, dissection, and rupture

BACKGROUND: Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal condition. Identifying mechanisms that drive aortic degeneration is a crucial step in developing an effective pharmacologic t...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Luo, Wei, Wang, Yidan, Zhang, Lin, Ren, Pingping, Zhang, Chen, Li, Yanming, Azares, Alon R., Zhang, Michelle, Guo, Jiao, Ghaghada, Ketan B., Starosolski, Zbigniew A., Rajapakshe, Kimal, Coarfa, Cristian, Li, Yumei, Chen, Rui, Fujiwara, Keigi, Abe, Jun-ichi, Coselli, Joseph S., Milewicz, Dianna M., LeMaire, Scott A., Shen, Ying H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939474/
https://ncbi.nlm.nih.gov/pubmed/31887080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.041460
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