DNA sensing via the Stimulator of Interferon Genes (STING) adaptor in myeloid dendritic cells induces potent tolerogenic responses()

Cytosolic DNA sensing via the STING adaptor incites autoimmunity by inducing type I IFN (IFNαβ). Here we show that DNA is also sensed via STING to suppress immunity by inducing indoleamine 2,3 dioxygenase (IDO). STING gene ablation abolished IFNαβ and IDO induction by dendritic cells (DCs) after DNA...

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Detalhes bibliográficos
Main Authors: Huang, Lei, Li, Lingqian, Lemos, Henrique, Chandler, Phillip R., Pacholczyk, Gabriela, Baban, Babak, Barber, Glen N., Hayakawa, Yoshihiro, McGaha, Tracy L., Ravishankar, Buvana, Munn, David H., Mellor, Andrew L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788571/
https://ncbi.nlm.nih.gov/pubmed/23986532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301419
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