DNA sensing via the Stimulator of Interferon Genes (STING) adaptor in myeloid dendritic cells induces potent tolerogenic responses()

Cytosolic DNA sensing via the STING adaptor incites autoimmunity by inducing type I IFN (IFNαβ). Here we show that DNA is also sensed via STING to suppress immunity by inducing indoleamine 2,3 dioxygenase (IDO). STING gene ablation abolished IFNαβ and IDO induction by dendritic cells (DCs) after DNA...

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Main Authors: Huang, Lei, Li, Lingqian, Lemos, Henrique, Chandler, Phillip R., Pacholczyk, Gabriela, Baban, Babak, Barber, Glen N., Hayakawa, Yoshihiro, McGaha, Tracy L., Ravishankar, Buvana, Munn, David H., Mellor, Andrew L.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788571/
https://ncbi.nlm.nih.gov/pubmed/23986532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301419
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