Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells

Nanoparticles containing DNA complexed with the cationic polymer polyethylenimine (PEI)(2) are efficient vehicles to transduce DNA into cells and organisms. DNA/PEI nanoparticles (DNPs) also elicit rapid and systemic release of pro-inflammatory cytokines that promote anti-tumor immunity. Here we rep...

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Bibliografiske detaljer
Main Authors: Huang, Lei, Lemos, Henrique P., Li, Lingqian, Li, MingHui, Chandler, Phillip R., Baban, Babak, McGaha, Tracy L., Ravishankar, Buvana, Lee, Jeffrey R., Munn, David H., Mellor, Andrew L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349160/
https://ncbi.nlm.nih.gov/pubmed/22516958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103668
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